Multiple production, research and utility facilities would be set up on Droo, Luna, Cylero, even Boreas.
Player would have to fly the craft from one point to the other to set up supply line, as the flight time, cost, cargo size / volume ( 3 dimensions independently), cargo mass being saved upon craft recovery. The data would be used to update the productivity and inventory data of each site, generating profit passively or generate new tech points which would be used to unlock different tech nodes apart from existing ones.
Once a supply line (flight) is set up, player could select the frequency of the flight, so the productivity / inventory data could be updated repeatedly and automatically, even include the service facility utilization data (as craft occupies parking / maintenance space which is limited on each site).
Perhaps craft launch requirement would be more than fund and size limit, involving the availability of parts, tools, fuel, life support supply, operation personnel of respective launch site. This would encourage economic and reliable craft design, even introduce a more in-depth management type game experience.
Some realistic scenario could be added, like transporting aircraft / rocket component to the assembly plant or launch site, actual commercial flight carrying hundreds of passengers, oversized cargo, air drop supply / aerial refueling, emergency deployment / urgent delivery, etc.